Bipolar Disorders Network

History

In 2009 several European researchers developed ENBREC, a disease-oriented EU-wide network designed to foster collaboration between expert centers specialized in research and clinical management of bipolar disorders. This project was funded by FP7 as a support action to set-up the network infrastructure and was also supported by the section for European Network Initiatives of the European College of Neuropsychopharmacology (ECNP-ENI). ENBREC provided an EU-integrated facility for research on underlying mechanisms in bipolar disorder, its epidemiology, diagnosis, and treatment. From this initiative stemmed the ECNP Bipolar Disorders Network which continues fostering harmonization of clinical and neurobiological research efforts in bipolar disorders.

The Bipolar Disorders Network is poised to facilitate clinical and translational research that can provide insights on the neurobiology of the disorder, improve efficiency of the drug discovery pipeline and inform treatment decision making. A specific focus is the development of research initiatives that can drive the development of multimodal predictive models for the risk of bipolar disorder and for mapping the trajectory of its clinical course. We foresee an increasing role of Network science in bipolar disorders essential for the harmonization of the phenotypes, reduction of heterogeneity and improvement of clinical outcomes that still show suboptimal response.

Mirko Manchia, Italy, and Eva Reininghaus, Austria.

Goals

Foster research activities in clinical and neurobiological areas of bipolar disorders.

Facilitate collaboration among research centers in bipolar disorder within EU and associated countries.

Promote interactions between the members of research groups participating in the Network.

Facilitate the development of large-scale collaborative efforts focused on data harmonization and sharing among centers.

Encourage the preparation of research proposals for the repurposing of drugs for bipolar disorders.

Mirko Manchia

University of Cagliari
Italy

Chair

Eva Reininghaus

Medical University of Graz
Austria

Co-chair

Core members

Member name	Institution	City	Country
Ole Andreassen	Oslo University Hospital	Oslo	Norway
Michael Bauer	Technische Universität Dresden	Dresden	Germany
Frank Bellivier	INSERM	Paris	France
Veerle Bergink	Erasmus University Medical Center	Rotterdam	The Netherlands
Deniz Ceylan	Koc University	Istanbul	Türkiye
Max de Leeuw	Leiden University Medical Center	Leiden	The Netherlands
Ana Gonzalez-Pinto	Hospital Santiago Apostol	Vitoria	Spain
Tomas Hajek	Dalhousie University	Halifax	Canada
Lars Vedel Kessing	Psychiatric Center Copenhagen	Copenhagen	Denmark
Mikael Landen	University of Gothenburg	Gothenburg	Sweden
Pavol Mikolas	Technische Universität Dresden	Dresden	Germany
René Ernst Nielsen	Aalborg University Hospital	Aalborg	Denmark
Andreas Reif	University Hospital Frankfurt	Frankfurt	Germany
Philipp Ritter	Carl Gustav Carus University Hospital	Dresden	Germany
Gonzalo Salazar de Pablo	King's College London	London	United Kingdom
Thomas Schulze	Ludwig Maximilian University of Munich	Munich	Germany
Jan Scott	University of Newcastle	Newcastle	United Kingdom
Alessio Squassina	University of Cagliari	Cagliari	Italy
Eduard Vieta	Fundació Clínic for the Biomedical Research	Barcelona	Spain
Nefize Yalin	National Institute for Mental Health	Maryland	USA
Aysegul Yildiz	Dokuz Eylül University	Izmir	Türkiye

Shell members

Member name	Institution	City	Country
Andreas Bechdolf	Vivantes Klinikum am Urban	Berlin	Germany
Hilary Blumberg	Yale School of Medicine	New Haven	USA
Hidayet Ece Arat Çelik	Maltepe University	Istanbul	Turkey
Annemiek Dols	University Medical Center	Utrecht	The Netherlands
Bruno Etain	University of Paris	Paris	France
Andrea Fagiolini	University of Siena	Siena	Italy
John Geddes	University of Oxford	Oxford	United Kingdom
Guy Goodwin	University of Oxford	Oxford	United Kingdom
Benno Haarman	University of Groningen	Groningen	The Netherlands
Chantal Henry	Hospital Albert Chenevier	Creteil	France
Ralph Kupka	VU University Medical Center Amsterdam	Amsterdam	The Netherlands
Trine Vik Lagerberg	Oslo University Hospital	Oslo	Norway
Rasmus Licht	Aalborg University Hospital	Aalborg	Denmark
Monica Martinez-Cengotitabengoa	Hospital Universitario Araba-Santiago	Vitoria	Spain
Gunnar Morken	St. Olav's University Hospital Norwegian University of science and Technology	Trondheim	Norway
Marcella Rietschel	Heidelberg University	Mannheim	Germany
Emanuel Severus	Carl Gustav Carus University Hospital	Dresden	Germany
Maj Vinberg	University of Copenhagen	Copenhagen	Denmark

Early Career Academy members

Member name	Institution	City	Country
Maximilian Bayas	University Hospital Frankfurt am Main	Frankfurt am Main	Germany
Michele De Prisco	Institute of Neuroscience, Hospital Clinic, Barcelona		Barcelona	Spain
Hanne Lie Kjaerstad	Psychiatric Center Copenhagen	Frederiksberg	Denmark
Luisa Klahn	University of Gothenburg	Gothenburg	Sweden

Publications

Research projects

R-LiNK

To improve outcomes of bipolar I disorder cases prescribed lithium through the application of stratified approaches and optimize the early prediction of lithium response using a set of multi-modal biomarkers

Grant agreement no. 754907

REALMENT

The EU-funded REALMENT project aims to optimise the treatment of mental disorders through novel precision medicine strategies based on current pharmaceutical options.

Grant agreement no. 964874

Psych-STRATA

The project intends to analyze extensive clinical, genetic and biological data of psychiatric patients to establish criteria for early detection of treatment resistance, proposing treatment strategies for patients at risk.

Grant agreement no. 101057454

European Brain Research Area

Facilitate multidisciplinary collaboration, knowledge and data sharing, to support innovative translational research, from basic to clinical and public health research, for the benefit of patients, focusing on the transdiagnostic disease-modifying prevention of severe mental disorders and improved care for established bipolar disorders.

Grant agreement no. 825348

Meetings

Knowledge Hub

Research

Awards

Early Career

News

About

Bipolar Disorders Network

History

Goals

Member name

Institution

City

Country

Publications

Genome-wide association study identifies 30 loci associated with bipolar disorder.

Analysis of shared heritability in common disorders of the brain.

Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group.

Influence of birth cohort on age of onset cluster analysis in bipolar I disorder

Solar insolation in springtime influences age of onset of bipolar I disorder

Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

DSM-5 and ICD-11 criteria for bipolar disorder: Implications for the prevalence of bipolar disorder and validity of the diagnosis - A narrative review from the ECNP bipolar disorders network

Outcomes associated with different vaccines in individuals with bipolar disorder and impact on the current COVID-19 pandemic- a systematic review

A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe

Novel multimodal precision medicine approaches and the relevance of developmental trajectories in bipolar disorder

New genomics discoveries across the bipolar disorder spectrum implicate neurobiological and developmental pathways

Genomics yields biological and phenotypic insights into bipolar disorder

Research projects