ECNP Medicines Chest — List of drugs

List of drugs

ECNP Medicines Chest — List of drugs

Amines
Amino-acids
Peptides
Enzymes
Ion Channels

Please note: in some of the compounds below you will find a blue link. Please click on the links to access a detailed overview of those compounds.

Amines

Drug name	Target	Source	Original Clinical Indications	Possible studies
5HT
MDL100907	5HT2 receptor antagonist	(Merrell) Sanofi- Aventis	Tried in schizophrenia	Role of 5HT2 receptors in sleep Ppsychosis Ppsychedelics
Deramiclane	5HT1A receptor antagonist	AZ	Tried in depression and anxiety	5HT in mood and cognition
MSD 212 ? Roche also	5HT3 agonist	MSD	? Anxiety eating	Appetite Anxiety
Fenfluramine	5HT release	?	Appetite suppression	Measuring 5HT release capacity
mCPP	5HT2C agonist	None	5HT probe	Eating anxiety
WAY-100635	5-HT1A receptor antagonist	Wyeth	5-HT probe	Mood disorders
Dopamine
SCH 23390	D1 antagonist	Schering Plough		Cognition Schizophrenia Addiction
GSK598809	DRD3 antagonist	GSK		Addiction
Noradrenaline
Fluparoxan	a2 antagonist	Glaxo	? Depression	Cognition Schizophrenia
RX811059	a2 antagonist	Pierre Fabre	? Parkinson’s disease	Cognition Schizophrenia
Amibegron (SR-58,611A)	b3 agonist	Sanofi	Anxiety/GAD Depression/MDD
Acetylcholine
Nicotinic	a7 agonist	EVP 6124	Alzheimer's disease	Cognition ADHD Schizophrenia
Mixed
Various ratios	DAT, NET, SERT, etc.	DOV	Depression	Affective disorders Cognition

Amino-acids

Drug name	Target	Source	Original Clinical Indications	Possible studies
GABA-A
a5IA	a5 inverse agonist	MSD	AAMI	Down's syndrome
L828417 SL651498	a2/3 selective benzo receptor agonists	MSD Sanofi-Aventis	GAD	Emotion Sleep
Gaboxadol	a4d selective agonist	Lundbeck	Sleep	Thalamic-cortical function Alcoholism
	a3 selective agonist	Dove	No trials	Sleep Anxiety
XBD173	Neurosteroid receptor agonist	Novartis/DSP	Anxiety	Anxiety Addiction Neuroinflammation
GABA-B
Phaclofen	GABA-B antagonist	Novartis	Depression	Cognition Mood Addiction
Glutamate
Bitopertin	GLYt1 blocker	?	Schizophrenia Negative symptoms	Any NMDA-related functions
Org 25935	GLYt1 blocker	Organon/MSD	Schizophrenia Negative symptoms	Alcohol dependence Facilitation of CBT
SSR103800	GLYt1 blocker	Sanofi	Schizophrenia

Peptides

Drug name	Target	Source	Original Clinical Indications	Possible studies
Orexin
Almorexant	ORX1 antagonist	Actelion	Sleep	Addiction Cognition
GSK	ORX1 antagonist	GSK	Sleep	Addiction Cognition
SubP/NK
Vofipitant	NK1 antagonist	GSK	Not tested	Anxiety Addiction Pain
Many others	NK1 antagonists	MSD, Novartis, GSK
Saredutant	NK2 antagonists	Sanofi	Anxiety/GAD Depression/MDD
Osanetant	NK3 antagonists	Sanofi	Schizophrenia
Opioid
Kappa	Agonist	Upjohn		Addiction Mood
Mu inverse agonist		GSK – in trials still	Obesity	Addiction
Cannabinoid
Rimonabant	Cb1 antagonist	Sanofi	Obesity	Addiction Mood
Org 28611	CB1 agonist	MSD	Pain	Addiction
Org 28312	CB1&2 agonist	MSD	Pain	Addiction
Org 50189	CB1 antagonist	MSD	Pain	Addiction Affect
Vasopressin
Org 52186	V1b antagonist	Organon/MSD	Anxiety stopped in P1	Affective disorders
SSR149415	V1b antagonist	Sanofi	Anxiety/GAD Depression/MDD
Glucocorticoid
Various	GR antagonist	Organon/MSD	GAD	Stress Neurodegeneration
Estrogen
Various	ERa, ERb, Mixed	Organon/MSD	Women’s health	Cognition +

Enzymes

FAAH
URB597	FAAH Inhibitor	Kadmus/Organon/MSD	Pain	Addiction Parkinson’s disease Cognition

Ion Channels

AMPA
Farampator	AMPAkine	Organon/MSD	Schizophrenia	Cognition
Org 26576	2^nd Generation AMPA modulator	Organon/MSD	Schizophrenia	Cognition
Patented	3^nd Generation AMPA modulator	Organon/MSD	FIH completed	Cognition
Ih Channel
Patented	HCN1	Organon/MSD	Pain	Sleep